SubtiBank SubtiBank
rsbRD [2019-08-26 10:00:05]
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rsbRD [2019-08-26 10:00:05]

probably part of the [SW|stressosome], negative regulator of [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB] activity
locus
BSU_24760
pI
5.09
mw
31.66 kDa
protein length
278 aa Sequence Blast
gene length
837 bp Sequence Blast
function
control of [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB] activity
product
[protein|621357D1FB6AC1B0499732EFE226F982B26CE34E|RsbR] paralog
essential
no
synonyms
yqhA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue]

    • Gene

    Coordinates
    2,562,966 2,563,802

    The protein

    Paralogous protein(s)

  • [protein|F53C527995909A1CFA72C7BF919DD10EE175C6D7|RsbRB], [protein|5EEEDE60CE9E5CDAEBAB0E03AABDF1DF62F1F002|RsbRC], [protein|621357D1FB6AC1B0499732EFE226F982B26CE34E|RsbR], [protein|6C5397BA5839E4DB25B370B39B6DA702147DA8B7|YtvA]

    • Modification

  • phosphorylation on Thr-181 by [protein|ADC52A22950736A0435AEEEC43F7407878786A81|RsbT] [Pubmed|21362065]

    • Expression and Regulation

    Operons

    genes
    [gene|979D7A45EAD97C99015029400A85795061BAA367|rsbRD]
    description
    (according to [http://dbtbs.hgc.jp/COG/prom/yqhA.html DBTBS]) null

    sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|10482513], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]

    • regulation

  • expressed under stress conditions ([protein|search|SigB]) [Pubmed|10482513,20019076]
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    Biological materials

    Mutant

  • MGNA-C475 (yqhA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2473 NBRP B. subtilis, Japan]
  • BKE24760 ([gene|979D7A45EAD97C99015029400A85795061BAA367|rsbRD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE24760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTAATGAGTTACCTCC, downstream forward: _UP4_TGATGCCTTTGCCATGTTTA
  • BKK24760 ([gene|979D7A45EAD97C99015029400A85795061BAA367|rsbRD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK24760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTAATGAGTTACCTCC, downstream forward: _UP4_TGATGCCTTTGCCATGTTTA

    • References

  • 15312768,10482513,20019076,17726680,17218307,11157946,28271471,28727759